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Contraindicated. Cobicistat is often a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are related to significant and/or lifetime-threatening events.

ergotamine will raise the amount or outcome of tazemetostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

Often speak to your healthcare company to ensure the data shown on this page applies to your own instances.

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ergotamine will improve the level or influence of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, lower to, or carry on lonafarnib at setting up dose.

enasidenib will lessen the extent or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Enasidenib (a weak CYP3A4 inducer) may possibly reduce systemic exposure of CYP3A4 substrates. Monitor and regulate dose of substrate as clinically indicated.

Check Intently (1)glycerol phenylbutyrate will decrease the level or influence of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

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palbociclib will raise the level or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. The dose of sensitive CYP3A substrates using a slim therapeutic index may perhaps should be minimized if coadministered with palbociclib

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crofelemer increases amounts of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations anticipated website during the intestine; unlikely to inhibit systemically for the reason that minimally absorbed.

conivaptan will increase the stage or effect of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

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